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Anderson is a city in and the county seat of Madison County, Indiana.  It is the principal city of the Anderson, Indiana Metropolitan Statistical Area, and its population at the 2010 census was 56,129.

Anderson is the headquarters of the Church of God (Anderson) and home of Anderson University, which is affiliated with that denomination. The city is named for Chief William Anderson, whose mother was a Delaware Indian (Lenape) and whose father was of Swedish descent. Natural gas was discovered here, which led to the growth and prosperity of the town, as well as its eventual decline as the resource ran out.

In 2007, Anderson was ranked 98th in the Forbes List for 100 Best Places for Businesses among Smaller U.S. Metro areas.