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Bishopville is a city in and the county seat of Lee County, South Carolina. It has a total area of 2.4 square mile. 0.04 square miles of the area is water, and the rest is land. The city was settled in the late eighteenth century, and was initially called Singleton’s Crossroads. This was a leading cotton production center.

Retail trade, educational services and agriculture are the major commercial activities here. Tourism is also popular here, and they visit attractions such as Pearl Fryar's Topiary Garden, Emmett Acres Alpaca Farm, Lee State Park and the South Carolina Cotton Museum. There are four public schools in the city. Lee County-Butters Field Airport is the local hospital. The closest hospital is the Carolina Pines Regional Medical Center, located about 14 miles away in Hartsville. The cost of living here is 15.50% lower than the country average.

This place gets about 45 inches of rain annually. The number of days with measurable precipitation is 104. Snowfall is about 2 inches annually.