Brandywine is an unincorporated village located in the U.S. state of Maryland. It is within Prince George's County lies in the east and west of busy Maryland Route 5/U.S. Route 301, which join at Brandywine. It has a total area of 21.1 square miles at 38°41′55″N 76°50′57″W. The elevation is 220 feet above sea level. As of the 2010 census data, it had a total population of 6,719. The population density was 320/sq mi. Estimated per capita income in 2016 was $41,413. It has Zip code 20613.