The city of Caruthersville is located in the county of Pemiscot. It covers a total area of 13.57 sq. km. Industries related to advertising, arts and crafts, automotive, construction, apparel, freight forwarding, hotel, insurance, oil and lubrication, real estate and publishing, contribute to the economy in a positive way. Commercial spaces are utilized by night clubs, nurseries of plants and trees, rehabilitation services, resale shops and restaurants.