The city of Doniphan is located in the county of Ripley. It covers a total area of 3.57 sq. km. Industries related to advertising, alternative medicine, household appliances, automotive, finance, beverages, apparel, information technology, pharmaceuticals, hotel, oil and lubrication and real estate, contribute to the local economy in a positive way. Commercial spaces are utilized by stores of alternative medicine, finance, brew pubs, convenience stores, drug stores, discount stores and night clubs.