The town of Guilford is located in the county of Piscataquis. It covers a total area of 92.49 sq. km. The economy of the city revolves around industries involved in automotive, finance, apparel, pharmaceuticals, insurance, oil and lubrication, real estate and education. Commercial spaces available in the city is utilized by parks, drug stores, convenience stores, parks, clinics and restaurants, contributing to the economy in a positive way.