Manley Hot Springs is a census-designated place located in the U.S. state of Alaska. It is part of the Yukon-Koyukuk Census Area 5 miles of Tanana River to the north and 160 miles of Fairbanks to the west. The total land area of Manley Hot Springs is 54.3 square miles at 65°0′28″N 150°37′36″W. As of 2010 census data, the total population of Manley Hot Springs was 89 with a population density of 1.6/sq mi. Manley Hot Springs is using Zip code 99756.